What do you think that means in practical terms, seems a very esoteric concept to me
It is not. As far back as Griswold v. Connecticut the Supreme Court has held that Americans have the right to privacy in making the most personal of decisions regarding our personal lives and those things that are essential to who we are as individuals. This right was used to prohibit the Government from interfering with choices about who we can marry, if we can use contraception, and Abortion, but if the government had tried to get involved an a huge number of other personal decisions, the Supreme Court based on that right and the precedent that it is valid, would have struck those laws down.
When deciding the recent Abortion decision, the Supreme Court did not say.... Yes the right to privacy is essential to freedom but because a second life is involved, the embryo or fetus's right to life supercedes the right to privacy and thus is not covered... Instead they wiped out the entire right to Privacy saying it does not exist. Thus we as Americans did not just lose the right to Abortion, but we lost the right to the "Freedom to make the most personal of decisions for ourselves that make us who we are as individuals." The government is now free to make all kinds of laws about our personal choices and life.
Practically, if a State or the Fed wanted to say you MUST have a covid vaccine for example, they are free to pass such a law.
If they want to say all boys must be circumcised, they are free to do that.
If they want to say we cannot have any medical procedures using stem cells, they can do that.
If they want to outlaw plastic surgery, they can.
If they want to ban driving gas powered vehicles, they can.
I could go on forever... We lost the right to many freedoms.
Sure the government may never try to take those freedoms, but I sure slept better knowing we were guaranteed these freedoms, even if the Congress decided to take them.